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Elevated lipids are one of the strongest predictors of a CV event, and one of the most modifiable risk factors.8,9 It’s important to consider lifestyle modifications and which treatments may be needed to help patients with ASCVD at very high risk achieve the ACC ECDP–recommended LDL-C level of < 55 mg/dL.1
* First possible or definite CHD event, possible or definitive stroke event, coronary revascularization, CHD death, stroke death, unclassifiable death.
† Population-attributable fraction is an estimate of the proportion of an outcome that could be prevented if the value of a risk factor were replaced by a hypothetical, ideal value.
‡ Non-HDL-C.
2022 ACC Expert Consensus Decision Pathway recommendation for ASCVD patients at very high risk:1,§
§Very high-risk patients have a history of multiple major ASCVD events or 1 major ASCVD event and multiple high-risk conditions, as previously defined in the 2018 AHA/ACC Multisociety cholesterol management guideline.1,9
CTTC meta-analysis of major lipid secondary prevention statin trials conducted in 2010: median follow-up ~ 5 years, N = 169,138.
CTTC = Cholesterol Treatment Trialists’ Collaboration; CV = cardiovascular; LDL-C = low-density lipoprotein cholesterol.